Contemporary real life cardioversion of atrial fibrillation: Results from the multinational RHYTHM-AF study
Identifieur interne : 004232 ( Main/Exploration ); précédent : 004231; suivant : 004233Contemporary real life cardioversion of atrial fibrillation: Results from the multinational RHYTHM-AF study
Auteurs : Harry J. G. M. Crijns [Pays-Bas] ; Bob Weijs [Pays-Bas] ; Anna-Meagan Fairley [Pays-Bas] ; Thorsten Lewalter [Allemagne] ; Aldo P. Maggioni [Italie] ; Alfonso Martin [Espagne] ; Piotr Ponikowski [Pologne] ; M Rten Rosenqvist [Suède] ; Prashanthan Sanders [Australie] ; Mauricio Scanavacca [Brésil] ; Lori D. Bash [États-Unis] ; François Chazelle [France] ; Alexandra Bernhardt [Allemagne] ; Anselm K. Gitt [Allemagne] ; Gregory Y. H. Lip [Royaume-Uni] ; Jean-Yves Le Heuzey [France]Source :
- International journal of cardiology [ 0167-5273 ] ; 2014.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Aims: Electrical and pharmacological cardioversion (ECV, PCV) are important treatment options for symptomatic patients with recent onset atrial fibrillation (AF). RHYTHM-AF is an international registry of present-day cardioversion providing information that is not currently available on country differences and acute and long-term arrhythmia outcomes of ECV and PCV. Methods and results: 3940 patients were enrolled, of whom 75% underwent CV. All patients were followed for 2 months. There were large variations concerning mode of CV used, ECV being heterogeneous. A choice of PCV drug depended on the clinical patient profile. Sinus rhythm was restored in 89.7% of patients by ECV and in 69.1% after PCV. Among patients not undergoing CV during admission, 34% spontaneously converted to sinus rhythm within 24 h. ECV was most successful in patients pretreated with antiarrhythmic drugs (mostly amiodarone). PCV was enhanced by class Ic antiarrhythmic drugs; conversion rate on amiodarone was similar to that seen with rate control drugs. Female patients and those with paroxysmal and first detected AF as well as those without previous ECV responded well to PCV. The median duration of hospital stay was 16.2 and 24.0 h for ECV and PCV patients, respectively. There were very few CV-related complications regardless of mode of CV. Chronic maintenance of sinus rhythm was enhanced in patients on chronic antiarrhythmic drugs, beta-blockers or inhibitors of the renin-angiotensin system. Conclusions: Mode of CV varied significantly, but both PCV and ECV were safe and effective. Class Ic drugs were most effective conversion drugs, but amiodarone is used most frequently despite providing merely rate control rather than shorten time to conversion.
Affiliations:
- Allemagne, Australie, Brésil, Espagne, France, Italie, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
- Angleterre, Communauté de Madrid, District de Cologne, Midlands de l'Ouest, Rhénanie-du-Nord-Westphalie, Svealand, État de São Paulo, Île-de-France
- Birmingham, Bonn, Madrid, Paris, Stockholm, São Paulo
- Université de São Paulo
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Contemporary real life cardioversion of atrial fibrillation: Results from the multinational RHYTHM-AF study</title><author><name sortKey="Crijns, Harry J G M" sort="Crijns, Harry J G M" uniqKey="Crijns H" first="Harry J. G. M." last="Crijns">Harry J. G. M. Crijns</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Weijs, Bob" sort="Weijs, Bob" uniqKey="Weijs B" first="Bob" last="Weijs">Bob Weijs</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Fairley, Anna Meagan" sort="Fairley, Anna Meagan" uniqKey="Fairley A" first="Anna-Meagan" last="Fairley">Anna-Meagan Fairley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Lewalter, Thorsten" sort="Lewalter, Thorsten" uniqKey="Lewalter T" first="Thorsten" last="Lewalter">Thorsten Lewalter</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P." last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>ANMCO Research Center</s1><s2>Florence</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>ANMCO Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Alfonso" sort="Martin, Alfonso" uniqKey="Martin A" first="Alfonso" last="Martin">Alfonso Martin</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>University Hospital Severo Ochoa</s1><s2>Madrid</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medical University</s1><s2>Wroclaw</s2><s3>POL</s3><sZ>7 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Rosenqvist, M Rten" sort="Rosenqvist, M Rten" uniqKey="Rosenqvist M" first="M Rten" last="Rosenqvist">M Rten Rosenqvist</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sanders, Prashanthan" sort="Sanders, Prashanthan" uniqKey="Sanders P" first="Prashanthan" last="Sanders">Prashanthan Sanders</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital</s1><s2>Adelaide</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Scanavacca, Mauricio" sort="Scanavacca, Mauricio" uniqKey="Scanavacca M" first="Mauricio" last="Scanavacca">Mauricio Scanavacca</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>University of São Paulo</s1><s2>São Paulo</s2><s3>BRA</s3><sZ>10 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bash, Lori D" sort="Bash, Lori D" uniqKey="Bash L" first="Lori D." last="Bash">Lori D. Bash</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Merck Sharp & Dohme Corp.</s1><s2>Whitehouse Station, NJ</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Merck Sharp & Dohme Corp.</wicri:noRegion></affiliation></author><author><name sortKey="Chazelle, Francois" sort="Chazelle, Francois" uniqKey="Chazelle F" first="François" last="Chazelle">François Chazelle</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>MSD France</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bernhardt, Alexandra" sort="Bernhardt, Alexandra" uniqKey="Bernhardt A" first="Alexandra" last="Bernhardt">Alexandra Bernhardt</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institut für Herzinfarktforschung</s1><s2>Ludwigshafen</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion></affiliation></author><author><name sortKey="Gitt, Anselm K" sort="Gitt, Anselm K" uniqKey="Gitt A" first="Anselm K." last="Gitt">Anselm K. Gitt</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institut für Herzinfarktforschung</s1><s2>Ludwigshafen</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion></affiliation></author><author><name sortKey="Lip, Gregory Y H" sort="Lip, Gregory Y H" uniqKey="Lip G" first="Gregory Y. H." last="Lip">Gregory Y. H. Lip</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>University of Birmingham Centre for Cardiovascular Sciences, Department of Cardiology, City Hospital</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Le Heuzey, Jean Yves" sort="Le Heuzey, Jean Yves" uniqKey="Le Heuzey J" first="Jean-Yves" last="Le Heuzey">Jean-Yves Le Heuzey</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Hopital Europeen Georges Pompidou. René Descartes University</s1><s2>Paris</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0101446</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0101446 INIST</idno><idno type="RBID">Pascal:14-0101446</idno><idno type="wicri:Area/PascalFrancis/Corpus">000485</idno><idno type="wicri:Area/PascalFrancis/Curation">005976</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000379</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000379</idno><idno type="wicri:doubleKey">0167-5273:2014:Crijns H:contemporary:real:life</idno><idno type="wicri:Area/Main/Merge">004303</idno><idno type="wicri:Area/Main/Curation">004232</idno><idno type="wicri:Area/Main/Exploration">004232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Contemporary real life cardioversion of atrial fibrillation: Results from the multinational RHYTHM-AF study</title><author><name sortKey="Crijns, Harry J G M" sort="Crijns, Harry J G M" uniqKey="Crijns H" first="Harry J. G. M." last="Crijns">Harry J. G. M. Crijns</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Weijs, Bob" sort="Weijs, Bob" uniqKey="Weijs B" first="Bob" last="Weijs">Bob Weijs</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Fairley, Anna Meagan" sort="Fairley, Anna Meagan" uniqKey="Fairley A" first="Anna-Meagan" last="Fairley">Anna-Meagan Fairley</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</s1><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Department of Cardiology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Lewalter, Thorsten" sort="Lewalter, Thorsten" uniqKey="Lewalter T" first="Thorsten" last="Lewalter">Thorsten Lewalter</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P." last="Maggioni">Aldo P. Maggioni</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>ANMCO Research Center</s1><s2>Florence</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>ANMCO Research Center</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Alfonso" sort="Martin, Alfonso" uniqKey="Martin A" first="Alfonso" last="Martin">Alfonso Martin</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>University Hospital Severo Ochoa</s1><s2>Madrid</s2><s3>ESP</s3><sZ>6 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medical University</s1><s2>Wroclaw</s2><s3>POL</s3><sZ>7 aut.</sZ></inist:fA14><country>Pologne</country><wicri:noRegion>Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Rosenqvist, M Rten" sort="Rosenqvist, M Rten" uniqKey="Rosenqvist M" first="M Rten" last="Rosenqvist">M Rten Rosenqvist</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>8 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sanders, Prashanthan" sort="Sanders, Prashanthan" uniqKey="Sanders P" first="Prashanthan" last="Sanders">Prashanthan Sanders</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centre for Heart Rhythm Disorders, University of Adelaide and Royal Adelaide Hospital</s1><s2>Adelaide</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Scanavacca, Mauricio" sort="Scanavacca, Mauricio" uniqKey="Scanavacca M" first="Mauricio" last="Scanavacca">Mauricio Scanavacca</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>University of São Paulo</s1><s2>São Paulo</s2><s3>BRA</s3><sZ>10 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Bash, Lori D" sort="Bash, Lori D" uniqKey="Bash L" first="Lori D." last="Bash">Lori D. Bash</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Merck Sharp & Dohme Corp.</s1><s2>Whitehouse Station, NJ</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Merck Sharp & Dohme Corp.</wicri:noRegion></affiliation></author><author><name sortKey="Chazelle, Francois" sort="Chazelle, Francois" uniqKey="Chazelle F" first="François" last="Chazelle">François Chazelle</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>MSD France</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bernhardt, Alexandra" sort="Bernhardt, Alexandra" uniqKey="Bernhardt A" first="Alexandra" last="Bernhardt">Alexandra Bernhardt</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institut für Herzinfarktforschung</s1><s2>Ludwigshafen</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion></affiliation></author><author><name sortKey="Gitt, Anselm K" sort="Gitt, Anselm K" uniqKey="Gitt A" first="Anselm K." last="Gitt">Anselm K. Gitt</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institut für Herzinfarktforschung</s1><s2>Ludwigshafen</s2><s3>DEU</s3><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Ludwigshafen</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion><wicri:noRegion>Institut für Herzinfarktforschung</wicri:noRegion></affiliation></author><author><name sortKey="Lip, Gregory Y H" sort="Lip, Gregory Y H" uniqKey="Lip G" first="Gregory Y. H." last="Lip">Gregory Y. H. Lip</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>University of Birmingham Centre for Cardiovascular Sciences, Department of Cardiology, City Hospital</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>15 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Le Heuzey, Jean Yves" sort="Le Heuzey, Jean Yves" uniqKey="Le Heuzey J" first="Jean-Yves" last="Le Heuzey">Jean-Yves Le Heuzey</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Hopital Europeen Georges Pompidou. René Descartes University</s1><s2>Paris</s2><s3>FRA</s3><sZ>16 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrial fibrillation</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Cardioversion</term><term>Heart rate</term><term>Instrumentation therapy</term><term>Result</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Fibrillation auriculaire</term><term>Accident cérébrovasculaire</term><term>Pathologie de l'appareil circulatoire</term><term>Cardioversion</term><term>Résultat</term><term>Rythme cardiaque</term><term>Cardiologie</term><term>Traitement instrumental</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aims: Electrical and pharmacological cardioversion (ECV, PCV) are important treatment options for symptomatic patients with recent onset atrial fibrillation (AF). RHYTHM-AF is an international registry of present-day cardioversion providing information that is not currently available on country differences and acute and long-term arrhythmia outcomes of ECV and PCV. Methods and results: 3940 patients were enrolled, of whom 75% underwent CV. All patients were followed for 2 months. There were large variations concerning mode of CV used, ECV being heterogeneous. A choice of PCV drug depended on the clinical patient profile. Sinus rhythm was restored in 89.7% of patients by ECV and in 69.1% after PCV. Among patients not undergoing CV during admission, 34% spontaneously converted to sinus rhythm within 24 h. ECV was most successful in patients pretreated with antiarrhythmic drugs (mostly amiodarone). PCV was enhanced by class Ic antiarrhythmic drugs; conversion rate on amiodarone was similar to that seen with rate control drugs. Female patients and those with paroxysmal and first detected AF as well as those without previous ECV responded well to PCV. The median duration of hospital stay was 16.2 and 24.0 h for ECV and PCV patients, respectively. There were very few CV-related complications regardless of mode of CV. Chronic maintenance of sinus rhythm was enhanced in patients on chronic antiarrhythmic drugs, beta-blockers or inhibitors of the renin-angiotensin system. Conclusions: Mode of CV varied significantly, but both PCV and ECV were safe and effective. Class Ic drugs were most effective conversion drugs, but amiodarone is used most frequently despite providing merely rate control rather than shorten time to conversion.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>Midlands de l'Ouest</li><li>Rhénanie-du-Nord-Westphalie</li><li>Svealand</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Bonn</li><li>Madrid</li><li>Paris</li><li>Stockholm</li><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Crijns, Harry J G M" sort="Crijns, Harry J G M" uniqKey="Crijns H" first="Harry J. G. M." last="Crijns">Harry J. G. M. Crijns</name></noRegion><name sortKey="Fairley, Anna Meagan" sort="Fairley, Anna Meagan" uniqKey="Fairley A" first="Anna-Meagan" last="Fairley">Anna-Meagan Fairley</name><name sortKey="Weijs, Bob" sort="Weijs, Bob" uniqKey="Weijs B" first="Bob" last="Weijs">Bob Weijs</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Lewalter, Thorsten" sort="Lewalter, Thorsten" uniqKey="Lewalter T" first="Thorsten" last="Lewalter">Thorsten Lewalter</name></region><name sortKey="Bernhardt, Alexandra" sort="Bernhardt, Alexandra" uniqKey="Bernhardt A" first="Alexandra" last="Bernhardt">Alexandra Bernhardt</name><name sortKey="Gitt, Anselm K" sort="Gitt, Anselm K" uniqKey="Gitt A" first="Anselm K." last="Gitt">Anselm K. Gitt</name></country><country name="Italie"><noRegion><name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P." last="Maggioni">Aldo P. Maggioni</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martin, Alfonso" sort="Martin, Alfonso" uniqKey="Martin A" first="Alfonso" last="Martin">Alfonso Martin</name></region></country><country name="Pologne"><noRegion><name sortKey="Ponikowski, Piotr" sort="Ponikowski, Piotr" uniqKey="Ponikowski P" first="Piotr" last="Ponikowski">Piotr Ponikowski</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Rosenqvist, M Rten" sort="Rosenqvist, M Rten" uniqKey="Rosenqvist M" first="M Rten" last="Rosenqvist">M Rten Rosenqvist</name></region></country><country name="Australie"><noRegion><name sortKey="Sanders, Prashanthan" sort="Sanders, Prashanthan" uniqKey="Sanders P" first="Prashanthan" last="Sanders">Prashanthan Sanders</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Scanavacca, Mauricio" sort="Scanavacca, Mauricio" uniqKey="Scanavacca M" first="Mauricio" last="Scanavacca">Mauricio Scanavacca</name></region></country><country name="États-Unis"><noRegion><name sortKey="Bash, Lori D" sort="Bash, Lori D" uniqKey="Bash L" first="Lori D." last="Bash">Lori D. Bash</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Chazelle, Francois" sort="Chazelle, Francois" uniqKey="Chazelle F" first="François" last="Chazelle">François Chazelle</name></region><name sortKey="Le Heuzey, Jean Yves" sort="Le Heuzey, Jean Yves" uniqKey="Le Heuzey J" first="Jean-Yves" last="Le Heuzey">Jean-Yves Le Heuzey</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lip, Gregory Y H" sort="Lip, Gregory Y H" uniqKey="Lip G" first="Gregory Y. H." last="Lip">Gregory Y. H. Lip</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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